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Chih-Ting Lin1,3 Li-Wei Lin1 Lung-Yuan Wu11,2,*
1 The School of Chinese Medicine for Post-Baccalaureate of I-Shou University, Kaohsiung, Taiwan
2 Wu, Lang-Yuan Tradition Chinese Medicine Clinic. Taipei, Taiwan
3 Department of Chinese Medicine, E-Da Cancer Hospital, Kaohsiung City , Taiwan
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Objective: The intention of this study was to organize the prescriptions and TCMs, used in Danxi’s Mastery of Medicine (DMM), to treat upper gastrointestinal diseases (UGID). Also, we expounded the cogitation of clinical syndrome differentiation, the distinguishing feature of prescriptions, and correlation analysis of TCMs. To provide clinical guidelines Chinese medical physicians can consult to treat UGIDs.
Method: In this study, we collected and sorted the chapters of chinese medicine disease names related to UGIDs in DDM, and their corresponding Chinese internal medicine prescriptions. We also exerted Microsoft 365 Excel to statisticize the frequency of TCM information. IBM SPSS Statistics 18 and Cytoscape 3.9.0 were utilized for complex network analysis of TCMs to find high-frequency core medication module. For the high-frequency core TCMs, Apriori algorithm and Pearson correlation coefficient hierarchical agglomeration analysis methods were used to analyze the association rules to find out the combination of TCM association rules and their corresponding prescriptions.
Result: The high-frequency core drugs used in the treatment of UGIDs in DDM included Zhigancao, Tangerine peel, Pinellia, Atractylodes, Ginseng, Poria, Amomum, Atractylodes, Cyperus officinalis, Rhizoma Coptidis. High-frequency efficacy classifications included Qi-invigorating, Qi-regulating, internal-warning, dampness-removing. Commonly used medicinal properties were warm, cold, and mild. Frequently used medicinal flavors were evenly distributed with acrid, sweet and bitter. Main meridians were spleen and stomach meridians. The association analysis combinations obtained by the Apriori algorithm can be classified as the addition and subtraction of Sijunzi decoction and Erchen decoction. While, eight drug association rules were obtained by the Pearson-correlation-coefficient hierarchical agglomeration analysis method.
Conclusion: Zhu Danxi’s syndrome-differentiating thoughts of gastrointestinal diseases paid attention to the etiology and pathogenesis of spleen deficiency, phlegm, dampness, and Qi stagnation. The treatment method mainly focuses on warming and supplementing the spleen and stomach, regulating Qi, and removing dampness and phlegm. In conclusion, these concepts were consistent with the results of our study.
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264.1 中醫臨床治療上消化道疾病的用藥規律分析——以《丹溪心法》為例
