中醫藥研究論叢

254.6 由子宮內膜異位症病案一例探討龍膽瀉肝湯對血清CA-125指數之影響

 TJ TCM.25(4) : 59-70, 2022

DOI : 10.6516/TJTCM.202212_25(4).0006
 
由子宮內膜異位症病案一例探討龍膽瀉肝湯
對血清CA-125 指數之影響
Endometriosis with High Level of CA-125 Treated with Traditional Chinese Medicine
and Influenced by its Dosage: A Case Report
吳宜潔1 謝瓊慧2 邱亭3*
1 泉安堂中醫診所,新北市,台灣
2,3 台北市立聯合醫院中興院區中醫科,台北市,台灣
【摘要】
子宮內膜異位症是婦科常見的疾病,可導致痛經和不孕。而血清CA-125 廣泛地作為子宮內膜異位症的腫瘤生物標記,可用作追蹤子宮內膜異位症治療成效及術後復發的參考。本病例為31 歲患有子宮內膜異位症(左側巧克力囊腫)的女性,因長期有經痛及帶下黃稠的症狀,且CA-125 指數偏高,經中醫辨證論治,診斷為肝氣鬱結,濕熱瘀阻,使用科學中藥龍膽瀉肝湯及桂枝茯苓丸合方加減治療後症狀改善且CA-125 下降,但在桂枝茯苓丸劑量不變之下,隨著龍膽瀉肝湯使用劑量下降至3g/ 天時,經痛等症狀加重且CA-125 指數又上升。此治療經驗顯示3g/ 天以下無法有效改善患者濕熱下注的情形,故瘀熱內阻症狀又再起,反映在CA-125 指數方面,則是數值再度升高,但仍需更多研究及病例追蹤探討之。
【關鍵詞】子宮內膜異位症、巧克力囊腫、CA-125、龍膽瀉肝湯、劑量
 
Yi-Jie Wu1Chiung-Hui Hsieh2Ting Chiu3*
1Chyuan An Tarng Chinese Medicine Clinics, New Taipei, Taiwan
2,3Department of Chinese Medicine, Taipei City Hospital Zhongxing Branch, Taipei, Taiwan
【Summary】
Endometriosis, one of the common gynecologic diseases in women of
reproductive age, may cause dysmenorrhea and infertility. Serum CA-125 is
a valuable tumor biomarker in the evaluation of treatment and follow-up of
recurrence in patients with endometriosis and initially elevated CA-125 level. This
case is a 31 y/o female who was diagnosed as? endometriosis with dysmenorrhea,
yellowish vaginal discharge, and elevated CA-125 level. According to TCM’s
theory, the patient was diagnosed with Qi Stagnancy in Liver and the blockade of
damp-heat and static blood. After the prescription of Longdan Xiegan Tang and
Guizhi Fuling Wan, which was aimed to relieving Qi stagnancy in Liver, clearing
damp-heat, and promoting blood circulation, the patient’s symptoms and CA-
125 level has improved. However, when the dosage of Longdan Xiegan Tang
decreased, the patient’s dysmenorrhea became severe, and CA-125 level elevated
again. Therefore, we deduced that the symptoms of blockade of damp-heat and
static blood could not be improved, so the CA-125 level elevated again when the
dosage of Longdan Xiegan Tang being reduced to 3g/day. But it is still necessary
to observe more cases and studies for actual conclusion.
 
【Keywords】Endometriosis; chocolate cyst; CA-125; Longdan Xiegan Tang; dosage