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Objectives: FOLFOX (5-FU/leucovorin/oxaliplatin) and FOLFIRI (Folinic acid/5-fluorouracil/irinotecan) are frequently used for colorectal cancer, and combined with target therapies. This study aims to investigate in using automatic tongue diagnosis system on the tongue features and properties of chemotherapy drugs by observation of the tongue features during chemotherapy process.
Methods: We recruited cancer patients who received chemotherapy in E-DA hospital for a year. We divided participants into three groups: FOLFOX group (N=9), FOLFIRI group (N=9), and another prescription group (N=11).
Results: As a result, the amount of tongue fur at the spleen and stomach area, kidney area, average area, and maximum area is more in FOLFOX group than in FOLFIRI group (p=0.041, 0.038, 0.026 and 0.03). The number of dental marks at left liver-gal area is more in FOLFIRI group than in FOLFOX group. The number of red dots is more in FOLFIRI group than in FOLFOX group at the spleen and stomach area (p=0.03).
Conclusions: Our study shows after FOLFOX treatment, the tongue fur area tends to increase, especially in the spleen-stomach and heart-lungs area. This outcome is consistent with previous findings that FOLFOX disturb the spleen-stomach system and result in the dampness accumulation. By contrast, the FOLFIRI increase the red dots at the spleen-stomach area and lead to more left liver-gal area dental marks than FOLFOX group. Our study shows FOLFIRI has the mixture properties with cold and heat.
【Keywords】Colorectal cancer; Chemotherapy; Tongue diagnosis; Automatic tongue
diagnosis system
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253.1 大腸直腸癌化療毒性與舌象特徵之關係：一觀察型研究
