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蕭坤元1,2 陳欣進3,4 陳俞沛5,6* 謝淑蘭2,4,7,8*
1 奇美醫學中心中醫部，台南，台灣
2 成功大學健康照護研究所，台南，台灣
3 中正大學心理系，嘉義，台灣
4 中正大學高齡跨域創新研究中心，嘉義，台灣
5 衛生福利部臺南醫院中醫科，台南，台灣
6 成功大學醫學系，台南，台灣
7 成功大學心理系，台南，台灣
8 成功大學公共衛生學系，台南，台灣
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Kun-Yuan Hsiao1,2 Hsin-Chin Chen3,4 Yu-Pei Chen5,6* Shulan Hsieh2,4,7,8*
1Department of Traditional Chinese Medicine, Chi Mei Medical Center, Tainan, Taiwan
2Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan
3Department of Psychology, National Chung Cheng University, Chiayi, Taiwan
4Center for Innovative Research on Aging Society (CIRAS), National Chung Cheng University, Taiwan
5Department of Traditional Chinese Medicine, Tainan Hospital, Ministry of Health and
Welfare, Tainan, Taiwan
6Department of Medicine, National Cheng Kung University, Tainan, Taiwan
7Department of Psychology, National Cheng Kung University, Tainan, Taiwan
8Department and Institute of Public Health, National Cheng Kung University, Tainan, Taiwan
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Objective: Alzheimer’s disease (AD) and mild cognitive impairment (MCI) are associated with aging and have become major health concerns. In addition, population aging is prominent worldwide. Medication is not the only method of treating AD and MCI; some nonmedication treatments have been under development, such as acupoint stimulation and acupuncture. The purpose of the current study was to evaluate the clinical efficacy of acupoint stimulation for improving cognitive function in patients with AD or MCI.
Methods: We searched for articles in 10 databases. The articles had to satisfy the following conditions: (1) elderly patients with AD or MCI; (2) an experimental group that received acupoint stimulation; and (3) a comparison group that received a control treatment, sham treatment, or any medication. The cognitive evaluation results were aggregated and integrated into our analysis. Moreover,the methodologies in the articles were assessed using Jadad scoring. The Mini-Mental State Examination (MMSE) was the most commonly used indicator in the identified studies for assessing cognitive function.
Results: The results of our meta-analysis based on the MMSE indicated that the effect of acupoint stimulation was superior to those of drug and control treatments. Furthermore, the results based on the integration of standardized indicators showed similar outcomes. Publication bias was significant in the analysis of standardized indicators but not of the MMSE, however, the tests of Fail-safe N suggested that the publication bias may have had little effect on the results of the meta-analysis.
Conclusion: According to this study, acupoint stimulation had superior efficacy compared with drug therapy and control treatment for improving cognitive function in patients with AD or MCI. This demonstrated that acupuncture stimulation may be a viable option for treatment.
【Keywords】Acupuncture; Alzheimer’s Disease; Mild Cognitive Impairment;
Meta-Analysis
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243.1 Acupoints Stimulation for Alzheimer’s Disease and Mild Cognitive Impairment: A Meta-Analysis
